Not a Laughing Matter: Effects of Tawa-tawa

Nigeria. Results ot the study snowed that botn the decoction and kick up of E. hirta, at doses of 60. 4 mg/kg and 483. 0 mg/kg have a significant printing on the thrombocyte aims of Sprague-Dawley rats. The red blood cell and WBC counts were non importantly affected, demonstrating that E. hirta does non affect the circulating RBC or the erythropoietic centers of the experimental animals, and it does not induce issue or remainder of the WBC. The mean accessions in thrombocyte count in the decoction and ethanolic excerption throngs did not importantly differ, suggesting that oth preparations can be used for provided studies.The residual in the mean platelet counts of sub conclaves who received the 60. 4 mg/kg and 483. 0 mg/kg doses was not significant as shown in Dunnets test. This decision indicated that the platelet- increasing action of E. hirta was not dose-dependent. The platelet-increasing activity of E. hirta was further evaluated by determining the effect of the p lant material on exhilarating platelet production in the drop marrow. In this military rating, the dose and preparation (483. g/kg of the ethanolic extract) that produced the greatest numerical adjoin in platelet count during the sign evaluation was used. Anagrelide, a drug which inhibits the suppuration of megakaryocytes into platelets, was administered to decrease the platelet counts of the test animals.After pictorial matter to anagrelide, 483. 0 mg/kg of ethanolic extract was administered to 50% of the test population. Results of this further evaluation showed that the mean platelet count did not differ significantly in the group which received both anagrelide (125 pg/day) nd ethanolic extract of E. irta (483. 0 mg/kg) and in the group who were only exposed to anagrelide (control). This suggested that the platelet-increasing activity of E. hirta was not due to stimulation of the platelet production in the bone marrow. 0 In another study conducted by the students of St. Mary s give lessons in Davao, E. hirta was also found to increase the platelet counts of white mice (Mus musculus). E. hirta was prepared in a teabag form. The results of this study were not published, and therefore, no further information was obtained.In Nigeria, the effects of sedimentary and methanolic extracts of E. hirta on platelet count, bleeding epoch, and clot time were also investigated. The extracts of E. hirta were administered orally to albino Wistar rats. thrombocyte count, bleeding time, and clotting time were rigid before, and at different time intervals by and by administration of the extracts. At 60 minutes, the aqueous extract reduced bleeding time by 54% compared to 49. 5% for methanolic extract, and the difference was significant.